Ice test as a simple diagnostic aid for myasthenia gravis

Acta Neurol Scand. 1994 Mar;89(3):227-9. doi: 10.1111/j.1600-0404.1994.tb01667.x.


It is known that myasthenia gravis is improved by cold. In two previously reported studies performed on a limited number of myasthenic patients and controls, local cold application to the eyelid was suggested for use as a diagnostic test for ocular myasthenia gravis. In this study, ice test to the eyelid was evaluated as a diagnostic test on 12 myasthenic patients and 15 controls with blepharoptosis and the results were compared with those of edrophonium test.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blepharoptosis / complications
  • Edrophonium
  • Female
  • Humans
  • Ice*
  • Male
  • Middle Aged
  • Myasthenia Gravis / complications
  • Myasthenia Gravis / diagnosis*
  • Neostigmine
  • Temperature


  • Ice
  • Neostigmine
  • Edrophonium