Influenza A virus replication is inhibited by tumor necrosis factor-alpha in vitro

Arch Virol. 1994;136(3-4):439-46. doi: 10.1007/BF01321073.


Treatment of Madin-Darby canine kidney (MDCK) cells with > or = 10 ng/ml of recombinant murine tumor necrosis factor-alpha (rmTNF-alpha) prior to inoculation with influenza A/PR/8/34, (H1N1), resulted in decreased production of infectious virus as determined by plaque assay, inhibition of viral protein synthesis and a reduction in cytopathic effect. The inhibition of viral replication in vitro suggests a role for TNF-alpha in the host's defense against influenza A virus infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Dogs
  • Influenza A virus / drug effects
  • Influenza A virus / physiology*
  • Mice
  • Tumor Necrosis Factor-alpha / pharmacology*
  • Virus Replication / drug effects*


  • Tumor Necrosis Factor-alpha