Extracorporeal circulation in the management of severe tricyclic antidepressant overdose

Am J Emerg Med. 1994 Jul;12(4):456-8. doi: 10.1016/0735-6757(94)90062-0.


Extracorporeal circulation is a technique that provides precise control of circulation, oxygenation, temperature, and blood composition in patients suffering from cardiopulmonary failure. The investigators present the case of a near fatal tricyclic antidepressant overdose that failed to respond to standard therapy but was resuscitated using extracorporeal circulation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Drug Overdose / complications
  • Drug Overdose / therapy
  • Extracorporeal Circulation*
  • Fatal Outcome
  • Female
  • Hemodynamics*
  • Humans
  • Hypotension / chemically induced*
  • Hypotension / physiopathology
  • Hypotension / therapy*
  • Imipramine / poisoning*
  • Severity of Illness Index
  • Treatment Failure


  • Imipramine