Position-effect variegation and the new biology of heterochromatin

Curr Opin Genet Dev. 1994 Apr;4(2):281-91. doi: 10.1016/s0959-437x(05)80055-3.


The phenomenon of position-effect variegation has long been used as evidence for the importance of chromosome position to gene expression in eukaryotes. Investigations published within the past few years demonstrate that position-effect variegation is caused by multiple mechanisms, and that direct tests of hypotheses are possible with numerous model systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Centromere
  • Chromatin / physiology
  • DNA
  • Drosophila / genetics
  • Gene Expression Regulation*
  • Heterochromatin*
  • Humans
  • Telomere


  • Chromatin
  • Heterochromatin
  • DNA