Distribution of prostaglandin E 9-KETOREDUCTASE AND TYPES I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex

Biochemistry. 1975 Jan 14;14(1):142-5. doi: 10.1021/bi00672a024.


Prostaglandin E 9-ketoreductase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I), and NADP+-dependent 15-hydroxyprostaglandin dehydrogenase (type II) have been partially purified from swine renal medulla and cortex. Eleven times more NAD+-dependent 15-hydroxyprostaglandin dehydrogenase activity was found in the cortex than in the medulla. On the other hand, about twice as much NADP+-dependent dehydrogenase activity was found in the medulla than in the cortex. The prostaglandin 9-ketoreductase activities were equally distributed in the swine kidney cortex and medulla.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohol Oxidoreductases / immunology
  • Alcohol Oxidoreductases / isolation & purification*
  • Alcohol Oxidoreductases / metabolism
  • Animals
  • Haplorhini / immunology
  • Kidney / enzymology*
  • Kidney Cortex / enzymology*
  • Kidney Medulla / enzymology*
  • Organ Specificity
  • Prostaglandins
  • Rabbits / immunology
  • Radioimmunoassay
  • Swine


  • Prostaglandins
  • Alcohol Oxidoreductases