The efficacy of controlled trials of alcohol misuse treatments in maintaining abstinence: a meta-analysis

Int J Addict. 1994 Apr;29(6):759-69. doi: 10.3109/10826089409047908.


Meta-analysis was used to establish the efficacy of various controlled alcohol misuse treatments in maintaining abstinence over short-term, 6-month, and 12-month follow-ups. Effect sizes were measured by odds ratio. Aggregate effect size differences between experimental and control groups were negligible. Only three of 15 studies found a clinically significant difference between treatment abstinence outcomes.

Publication types

  • Comparative Study
  • Meta-Analysis

MeSH terms

  • Alcoholism / therapy*
  • Cost-Benefit Analysis
  • Humans
  • Naltrexone / therapeutic use
  • Randomized Controlled Trials as Topic*
  • Temperance
  • Treatment Outcome


  • Naltrexone