Presence of anti-CSL antibodies in the cerebrospinal fluid of patients: a sensitive and specific test in the diagnosis of multiple sclerosis

J Neuroimmunol. 1994 Jul;52(2):175-82. doi: 10.1016/0165-5728(94)90111-2.


The carbohydrate-binding protein (lectin) CSL is an antigen involved in the stabilization of the myelin structure by interacting with the carbohydrate moiety of myelin glycoproteins. Since anti-CSL Fab fragments were able to produce destruction of CNS myelin in vitro, CSL was considered as a potential immunological target in multiple sclerosis. The presence of anti-CSL antibodies has been examined in the cerebrospinal fluid of 1388 different patients with various neurological diseases. It is concluded that the presence of anti-CSL antibodies in the cerebrospinal fluid of patients less than 50 years old constitutes a very sensitive and specific test for multiple sclerosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / cerebrospinal fluid*
  • Humans
  • Immunoblotting
  • Lectins / immunology*
  • Multiple Sclerosis / cerebrospinal fluid
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / immunology*
  • Nervous System Diseases / cerebrospinal fluid
  • Nervous System Diseases / immunology
  • Sensitivity and Specificity


  • Antibodies
  • Lectins
  • cerebellar soluble lectin