Viral replication and development of specific immunity in macaques after infection with different measles virus strains

J Infect Dis. 1994 Aug;170(2):443-8. doi: 10.1093/infdis/170.2.443.


Cynomolgus monkeys (Macaca fascicularis) were experimentally infected with a wild type measles virus (MV) strain (MV-BIL). Following intratracheal inoculation with different infectious doses, the virus could be isolated from peripheral blood mononuclear cells (PBMC), lung lavage cells, and pharyngeal cells. The kinetics of the cell-associated viremia was similar in all infected animals. They developed specific serum IgM, IgG, and neutralizing antibody responses as well as MV-specific T cell-mediated immunity. Monkeys infected intratracheally or intramuscularly with the wild type MV-Edmonston or the attenuated MV-Schwartz strain showed a lower level of PBMC-associated viremia and less pronounced specific IgM responses. Nine months after infection with MV strains, all of the monkeys were protected from intratracheal reinfection with MV-BIL. This monkey model is suitable for study of new generations of vaccines and vaccination strategies for measles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral / biosynthesis
  • Disease Models, Animal*
  • Humans
  • Immunity, Cellular
  • Immunoglobulin G / biosynthesis
  • Immunoglobulin M / biosynthesis
  • Kinetics
  • Leukocytes, Mononuclear / microbiology
  • Lung / cytology
  • Lung / microbiology
  • Macaca fascicularis*
  • Measles / immunology
  • Measles / microbiology*
  • Measles virus / immunology
  • Measles virus / physiology*
  • Pharynx / cytology
  • Pharynx / microbiology
  • T-Lymphocytes / immunology
  • Viremia / immunology
  • Viremia / microbiology
  • Virus Replication*


  • Antibodies, Viral
  • Immunoglobulin G
  • Immunoglobulin M