Colchicine disposition in patients with familial Mediterranean fever with renal impairment

J Rheumatol. 1994 Apr;21(4):710-3.

Abstract

Objective: To assess the pharmacokinetics of serum colchicine in patients with familial Mediterranean fever (FMF) with renal impairment.

Methods: Using a specific radioimmunoassay we determined serum colchicine concentration at various time points following oral administration of a single dose of the drug.

Results: Patients with renal insufficiency had a mean +/- SD apparent total colchicine clearance of 0.168 +/- 0.063 l/h/kg, apparent volume of distribution of 4.56 +/- 1.64 l/kg and elimination half-life (t1/2) of 18.8 +/- 1.2 h. Patients with FMF with normal kidney function had a mean clearance of 0.726 +/- 0.110 l/h/kg, volume of distribution of 4.87 +/- 2.05 l/kg and terminal t1/2 of 4.4 +/- 1.0 h.

Conclusion: The kidneys have an important role in the clearance of colchicine. Caution should be exercised in the use of colchicine in patients with renal insufficiency.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Colchicine / administration & dosage
  • Colchicine / blood
  • Colchicine / pharmacokinetics*
  • Familial Mediterranean Fever / complications
  • Familial Mediterranean Fever / drug therapy
  • Familial Mediterranean Fever / metabolism*
  • Female
  • Half-Life
  • Humans
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / metabolism*
  • Kidney Failure, Chronic / therapy
  • Male
  • Metabolic Clearance Rate
  • Renal Dialysis

Substances

  • Colchicine