Omega-conotoxin MVIIC reversibly inhibits a human N-type calcium channel and calcium influx into chick synaptosomes

Neuropharmacology. 1994 Feb;33(2):255-8. doi: 10.1016/0028-3908(94)90017-5.

Abstract

We have investigated the effects of omega-CmTX MVIIC on the recombinant alpha 1B-mediated calcium channel expressed in HEK 293 cells and on the predominantly N-type calcium channel in chick synaptosomes. omega-CmTX MVIIC potently and reversibly inhibited the calcium current through alpha 1B-mediated calcium channels and inhibited KCl-evoked increases in [Ca2+]i in chick synaptosomes in a concentration-dependent manner.

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Calcium / metabolism*
  • Calcium Channel Blockers / pharmacology*
  • Cell Line
  • Chickens
  • In Vitro Techniques
  • Peptides / pharmacology*
  • Synaptosomes / drug effects*
  • Synaptosomes / metabolism
  • Time Factors
  • omega-Conotoxins*

Substances

  • Calcium Channel Blockers
  • Peptides
  • omega-Conotoxins
  • omega-conotoxin-MVIIC
  • Calcium