Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation

J R Brasic; J Y Barnett; D Kaplan; B B Sheitman; P Aisemberg; R T Lafargue; S Kowalik; A Clark; M O Tsaltas; J G Young

doi:10.1212/wnl.44.7.1309

Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation

Neurology. 1994 Jul;44(7):1309-12. doi: 10.1212/wnl.44.7.1309.

Authors

J R Brasic¹, J Y Barnett, D Kaplan, B B Sheitman, P Aisemberg, R T Lafargue, S Kowalik, A Clark, M O Tsaltas, J G Young

Affiliation

¹ Department of Psychiatry, Bellevue Hospital Center, New York, NY.

PMID: 8035936
DOI: 10.1212/wnl.44.7.1309

Abstract

In an open, nonblind clinical trial, clomipramine reduced adventitious movements and compulsions in five previously medicated prepubertal boys with autistic disorder and severe mental retardation. Poorly adapted rating scales, interrater variability, subject heterogeneity, different treatment histories, and environmental stresses confounded the assessment of treatment effects.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Autistic Disorder / complications*
Child
Clomipramine / therapeutic use*
Humans
Intellectual Disability / complications*
Male
Movement Disorders / drug therapy*
Movement Disorders / etiology*
Movement Disorders / physiopathology
Puberty*
Severity of Illness Index
Treatment Outcome

Substances

Clomipramine