Effects of intraocular bubble duration in the treatment of macular holes by vitrectomy and transforming growth factor-beta 2

Ophthalmology. 1994 Jul;101(7):1195-200. doi: 10.1016/s0161-6420(94)31187-0.


Purpose: To compare the effect of a long-acting (16% perfluoropropane [C3F8]) versus a short-acting (air) intraocular gas tamponade on visual outcome and macular hole closure rate after vitrectomy and intravitreal instillation of transforming growth factor-beta 2 (TGF-beta 2) on the macula.

Methods: Vitrectomy with removal of the posterior hyaloid fluid-gas exchange with instillation of TGF-beta 2 was performed in 15 eyes treated with air and 37 eyes treated with 16% C3F8 using identical surgical techniques (mean follow-up, 5.6 months).

Results: The macular hole was closed successfully in 36 (97%) of 37 eyes treated with 16% C3F8 and in 8 (53.3%) of 15 eyes treated with air (P = 0.00007). The visual acuity improved by a mean of 3.1 lines on the Early Treatment of Diabetic Retinopathy Study chart for eyes treated with 16% C3F8 and 1.3 lines for eyes treated with air (P = 0.003).

Conclusions: A longer duration intraocular gas tamponade from 16% C3F8 gives a much higher rate of successful closure of macular holes and improved visual acuity using vitrectomy and TGF-beta 2 than does air.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Air*
  • Combined Modality Therapy
  • Female
  • Fluorocarbons / administration & dosage*
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Retinal Perforations / drug therapy
  • Retinal Perforations / surgery*
  • Time Factors
  • Transforming Growth Factor beta / therapeutic use*
  • Treatment Outcome
  • Visual Acuity
  • Vitrectomy*


  • Fluorocarbons
  • Transforming Growth Factor beta
  • perflutren