Colon cancer and DNA repair: have mismatches met their match?

Trends Genet. 1994 May;10(5):164-8. doi: 10.1016/0168-9525(94)90093-0.


Recently, both a common inherited human cancer, hereditary non-polyposis colorectal carcinoma (HNPCC), and certain sporadic human cancers have been shown to have frequent alterations in microsatellite sequences. These were ascribed to a defect in the correction of errors of replication; indeed, the cell line H6, which is derived from an HNPCC tumour, has been shown to be deficient in mismatch repair. The HNPCC locus on chromosome 2p has been linked to a gene hMSH2, which encodes a 100 kDa mismatch-binding protein that has an extensive degree of sequence conservation from bacteria through yeast to humans. But could a malfunction of this protein alone cause cancer?

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics*
  • DNA Repair*
  • DNA, Neoplasm / genetics*
  • DNA-Binding Proteins / genetics*
  • Humans
  • Molecular Sequence Data
  • MutS Homolog 2 Protein
  • Proto-Oncogene Proteins / genetics*


  • DNA, Neoplasm
  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • MSH2 protein, human
  • MutS Homolog 2 Protein

Associated data

  • GENBANK/M64730
  • GENBANK/M84169
  • GENBANK/U04045