Measurement of volumetric coronary blood flow by simultaneous intravascular two-dimensional and Doppler ultrasound: validation in an animal model

Am Heart J. 1994 Aug;128(2):237-43. doi: 10.1016/0002-8703(94)90474-x.


We examined the accuracy and feasibility of using simultaneous intracoronary Doppler and two-dimensional (2D) ultrasound imaging in the measurement of volumetric coronary blood flow (CBF). A femoral artery-to-circumflex coronary artery shunt was created in four dogs with tubing that incorporated an in-line transit-time ultrasound (TTU) flow probe. A 2D ultrasound catheter was introduced over a 0.014-inch Doppler guide wire into the circumflex artery with the guide wire tip positioned 2 cm beyond the imaging catheter tip. Cross-sectional area (CSA) and average peak velocity (APV) were recorded. CBF was determined from the previously validated relation CBF = CSA x 0.5 APV and the adjusted measurement formula CBF = CSA x 0.47 APV. Within the 119 measurements made, TTU CBF varied from 31 to 385 ml/min. An excellent correlation was found between 2D/Doppler-derived and TTU CBF with both constants; measurement agreement was improved and bias minimal with the 0.47 constant (slope = 0.9997; r = 0.99; p < 0.0001; SEE = -6.7 +/- 8.6). We conclude that simultaneous 2D and Doppler ultrasound yields accurate estimates of volumetric CBF.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Flow Velocity
  • Blood Volume
  • Coronary Circulation / physiology*
  • Coronary Vessels / diagnostic imaging*
  • Coronary Vessels / physiology
  • Dogs
  • Fourier Analysis
  • Linear Models
  • Models, Cardiovascular
  • Ultrasonography, Interventional* / instrumentation
  • Ultrasonography, Interventional* / methods