Molecular analysis of an asymptomatic Ph-positive CML patient with 27 years of prolonged remission

Am J Hematol. 1994 Aug;46(4):358-62. doi: 10.1002/ajh.2830460419.

Abstract

We describe the results of clinical, cytogenetic, and molecular biological studies of a patient who, after two courses of treatment with Busulphan, has remained free of symptoms of Philadelphia chromosome-positive chronic myeloid leukemia for 27 years, except for the persistence of a Ph1 chromosome and the presence of its transcribed chimeric mRNA.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Busulfan / therapeutic use
  • Chromosome Mapping
  • DNA, Neoplasm / analysis
  • Female
  • Gene Rearrangement
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / physiopathology
  • Polymerase Chain Reaction
  • Remission Induction
  • Retinoblastoma / genetics
  • Time Factors

Substances

  • DNA, Neoplasm
  • Busulfan