Limbic encephalitis secondary to malignant thymoma

Ann Thorac Surg. 1994 Jul;58(1):250-1. doi: 10.1016/0003-4975(94)91119-3.


A 56-year-old woman presented with memory loss and an enlarging mediastinal mass on chest roentgenogram. Physical findings were normal except for an altered mental status examination consistent with dementia. Further radiologic assessment was nondiagnostic. Surgical resection of a malignant thymoma resulted in clinical improvement. Treatment for limbic encephalitis should be directed at the underlying disease, and symptoms may improve if the tumor is eradicated.

Publication types

  • Case Reports

MeSH terms

  • Dementia / etiology
  • Encephalitis / etiology*
  • Female
  • Humans
  • Limbic System*
  • Memory Disorders / etiology
  • Mental Status Schedule
  • Middle Aged
  • Paraneoplastic Syndromes / etiology*
  • Thymoma / complications*
  • Thymoma / surgery
  • Thymus Neoplasms / complications*
  • Thymus Neoplasms / surgery