The recognition of cancer-associated fucosylated antigens in colorectal cancer by a novel monoclonal antibody, YB-2

Surg Today. 1994;24(4):382-4. doi: 10.1007/BF02348574.


A monoclonal antibody, YB-2, which has a novel epitope for fucosylated antigens and shows cross-reactivity with Y/Leb/H type 2 antigens, was used in an immunohistochemical study of human neoplastic and normal colorectal tissues. Of 64 colorectal cancers, 59 (92.2%) were stained by the YB-2 antibody; however, only 3 (12.0%) of 25 samples of normal colon mucosa and 13 (50.0%) of 26 adenomas expressed the antigens recognized by YB-2. Clinicopathologically, the YB-2-negative colon cancers were exclusively in Dukes stage A. These results indicate that the monoclonal antibody, YB-2, could detect cancer-associated antigens, and the degree of YB-2-reacted antigen expression might be correlated with the progression of colorectal carcinogenesis.

MeSH terms

  • Adenoma / immunology
  • Adenoma / pathology
  • Antibodies, Monoclonal / immunology*
  • Antigens, Neoplasm / analysis*
  • Carcinoma / immunology
  • Carcinoma / pathology
  • Colorectal Neoplasms / immunology*
  • Colorectal Neoplasms / pathology
  • Humans
  • Neoplasm Staging


  • Antibodies, Monoclonal
  • Antigens, Neoplasm