The mechanisms of schizophrenia

Curr Opin Neurobiol. 1994 Apr;4(2):245-51. doi: 10.1016/0959-4388(94)90080-9.


Current investigations of the mechanisms of schizophrenia usually employ one of three possible explanatory models: a single disease entity model, a multiple disease entity model, and a dimensions of psychopathology model. None of these is at present preeminent. These models are used to explore four different types of mechanisms that may produce the symptoms of schizophrenia: neurodevelopmental, neural circuitry, genetic/molecular mechanisms, and chemical anatomy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Brain / growth & development
  • Dopamine / metabolism
  • Humans
  • Models, Neurological*
  • Neural Pathways / physiopathology
  • Schizophrenia / genetics
  • Schizophrenia / metabolism
  • Schizophrenia / physiopathology*
  • Schizophrenic Psychology*


  • Dopamine