A novel human gene that is preferentially transcribed in heart muscle

Gene. 1994 Jul 8;144(2):301-6. doi: 10.1016/0378-1119(94)90394-8.


We have cloned a human cDNA fragment for a gene that is expressed primarily in the heart. To explore its biological function, we have isolated full-length cDNA clones of the gene. DNA sequencing of the 2.7-kb cDNA revealed a 2274-bp ORF. Close to the N terminus of the deduced amino acid sequence is a possible ATP-binding domain that has been assembled by a fusion of B- and A-type adenine nucleotide-binding motifs. In the middle of the sequence is a long stretch of alpha-helical residues that could form a coiled-coil. These features imply that this is a sequence encoding a new human motor protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Line
  • DNA, Complementary
  • Humans
  • Mitochondrial Proteins
  • Molecular Sequence Data
  • Muscle Proteins / genetics*
  • Muscle Proteins / metabolism
  • Myocardium / metabolism*
  • Protein Structure, Secondary
  • Rats
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Transcription, Genetic*


  • DNA, Complementary
  • IMMT protein, human
  • Mitochondrial Proteins
  • Muscle Proteins
  • Adenosine Triphosphate

Associated data

  • GENBANK/D11750
  • GENBANK/D21091
  • GENBANK/D21092
  • GENBANK/D21093
  • GENBANK/D21094
  • GENBANK/M85372
  • GENBANK/M85406
  • GENBANK/Z19322