Cloning and sequencing of the cDNA encoding a human testis phospholipid hydroperoxide glutathione peroxidase

Gene. 1994 Jul 8;144(2):317-8. doi: 10.1016/0378-1119(94)90400-6.


A human cDNA that encodes a polypeptide that has 94% deduced amino-acid sequence identity to porcine phospholipid hydroperoxide glutathione peroxidase was cloned from a testis library. The sequence shows preservation of the UGA selenocysteine codon, putative active-site Trp and Glu residues and a Tyr residue that is phosphorylated in the porcine protein. The 3'-UTR shows some conservation of sequences implicated in the insertion of selenocysteine at an opal codon in human glutathione peroxidase-1.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding Sites
  • Cloning, Molecular
  • DNA, Complementary
  • Glutathione Peroxidase / genetics*
  • Glutathione Peroxidase / metabolism
  • Humans
  • Male
  • Molecular Sequence Data
  • Phospholipid Hydroperoxide Glutathione Peroxidase
  • Phosphorylation
  • Testis / enzymology*


  • DNA, Complementary
  • Phospholipid Hydroperoxide Glutathione Peroxidase
  • Glutathione Peroxidase

Associated data

  • GENBANK/X71973