Novel aspartyl protease inhibitors, YF-0200R-A and B

J Antibiot (Tokyo). 1994 May;47(5):566-70. doi: 10.7164/antibiotics.47.566.


Novel pepstatin A-sensitive Candida albicans aspartyl protease inhibitors, named YF-0200R-A and B, were isolated by column chromatography and preparative HPLC from the fermentation broth of Streptomyces sp. YF-0200R. The structures of YF-0200R-A and B were elucidated by spectroscopic analysis as alpha, beta and gamma, delta unsaturated fatty acids with two or three hydroxyl groups. YF-0200R-A and B inhibit aspartyl protease from Candida albicans with IC50 values of 6.5 x 10(-4) M and 6.2 x 10(-4) M, respectively.

MeSH terms

  • Aspartic Acid Endopeptidases / antagonists & inhibitors*
  • Candida albicans / enzymology
  • Chemical Phenomena
  • Chemistry, Physical
  • Fatty Acids, Unsaturated / chemistry*
  • Fatty Acids, Unsaturated / isolation & purification
  • Fatty Acids, Unsaturated / pharmacology
  • Fermentation
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Protease Inhibitors / chemistry*
  • Protease Inhibitors / isolation & purification
  • Protease Inhibitors / pharmacology
  • Streptomyces / chemistry


  • Fatty Acids, Unsaturated
  • Protease Inhibitors
  • YF 0200R-A
  • YF 0200R-B
  • Aspartic Acid Endopeptidases