Synaptic organization of the amine-containing interplexiform cells of the goldfish and Cebus monkey retinas

Science. 1975 Apr 18;188(4185):270-3. doi: 10.1126/science.804181.


Fluorescence microscopy has revealed a new type of amine-containing retinal neuron, the interplexiform cell, that extends processes in both plexiform layers. After intravitreal injection of 5,6-dihydroxytryptamine in goldfish and Cebus monkey, the processes of these cells can be identified by electron microscopy. In goldfish, the processes are pre- and postsynaptic to amacrine cells in the inner plexiform layer and presynaptic to bipolar and horizontal cells in the outer plexiform layer. Interplexiform cells thus provide an intraretinal centrifugal pathway from inner to outer plexiform layers.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amines* / metabolism
  • Animals
  • Cyprinidae / anatomy & histology*
  • Goldfish / anatomy & histology*
  • Haplorhini / anatomy & histology*
  • Microscopy, Electron
  • Microscopy, Fluorescence
  • Models, Neurological
  • Neurons / cytology*
  • Neurons / metabolism
  • Neurons / ultrastructure
  • Retina / cytology*
  • Retina / metabolism
  • Retina / ultrastructure
  • Serotonin / administration & dosage
  • Synapses / ultrastructure*


  • Amines
  • Serotonin