High sensitivity of the in vivo detection of somatostatin receptors by 111indium (DTPA-octreotide)-scintigraphy in meningioma patients

Acta Neurochir (Wien). 1994;126(2-4):63-71. doi: 10.1007/BF01476412.


The recent availability of isotope-labelled somatostatin analogues has allowed one to detect somatostatin receptors in normal tissue as well as in endocrine or non-endocrine cranial tumours. The purpose of the present study was to establish the value of somatostatin receptor scintigraphy using an 111Indium-labelled somatostatin analogue, octreotide, in the diagnostic work-up of meningioma patients. Twenty-two patients (16 women, 6 men, aged from 19-70 years) with newly diagnosed, residual or recurrent cranial meningiomas were examined. 111Indium-labelled DTPA-octreotide was injected i.v.. Planar and tomographic images were obtained with a gamma camera 4-6, and 24 hours after injection. In all of the meningiomas studied a high density of somatostatin receptors was detected by scintigraphy. No false negative test result was found. Due to this, a 100% predictive value of a negative test was calculated. However, when the tumours were taken in culture differing staining intensity could be seen in the light- and electron microscopic level even on individual cells of a single culture when silver intensified somatostatin-gold was used as ligand. We conclude, that in vivo somatostatin receptor scintigraphy may aid in the pre-operative differential diagnosis of skull base tumours.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers, Tumor / analysis*
  • Female
  • Glial Fibrillary Acidic Protein / analysis
  • Humans
  • Indium*
  • Male
  • Meningeal Neoplasms / diagnostic imaging*
  • Meningeal Neoplasms / pathology
  • Meningeal Neoplasms / surgery
  • Meningioma / diagnostic imaging*
  • Meningioma / pathology
  • Meningioma / surgery
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Recurrence, Local / surgery
  • Octreotide / analogs & derivatives*
  • Pentetic Acid / analogs & derivatives*
  • Radionuclide Imaging
  • Receptors, Somatostatin / analysis*
  • Tumor Cells, Cultured / pathology


  • Biomarkers, Tumor
  • Glial Fibrillary Acidic Protein
  • Receptors, Somatostatin
  • Indium
  • SDZ 215-811
  • Pentetic Acid
  • Octreotide