Anti-annexin V Antibody in Systemic Lupus Erythematosus Patients With Lupus Anticoagulant and/or Anticardiolipin Antibody

Am J Hematol. 1994 Sep;47(1):56-8. doi: 10.1002/ajh.2830470112.

Abstract

We investigated anti-annexin V antibody (aANX) in patients with systemic lupus erythematosus (SLE), and correlated to positivity with lupus anticoagulant (LA)/anticardiolipin antibody (aCL). aANX was positive in 12/47 SLE patients (26%), including 7 with beta 2-glycoprotein 1 (GPI)-dependent aANX. The positivity of aANX was higher in patients with aCL (19%) and LA/aCL (50%) than in those without LA/aCL (10%). From these results, it is concluded that aANX is an autoantibody closely related to LA/aCL, and can be a possible new risk marker for thrombosis.

MeSH terms

  • Annexin A5 / immunology*
  • Antibodies / blood*
  • Antibodies, Anticardiolipin / blood*
  • Humans
  • Lupus Coagulation Inhibitor / blood*
  • Lupus Erythematosus, Systemic / blood
  • Lupus Erythematosus, Systemic / immunology*

Substances

  • Annexin A5
  • Antibodies
  • Antibodies, Anticardiolipin
  • Lupus Coagulation Inhibitor