Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver

Biochem Pharmacol. 1994 Jul 5;48(1):59-64. doi: 10.1016/0006-2952(94)90223-2.


Expression of human cytochrome P450 (CYP) genes in human adult and fetal liver were studied using the reverse transcriptase-polymerase chain reaction (RT-PCR) method. In adult liver mRNA of CYPs 1A1, 1A2, 2A6/2A7, 2B6/2B7, 2C8-19, 2D6, 2E1, 3A3/3A4 and 3A7 were detected while CYPs 2F1 and 4B1 were absent. In fetal liver mRNA of CYPs 2C8, 2D6, 3A3/3A4 and 3A7 were found but all other forms studied were undetectable. The results provide a comprehensive qualitative picture of the expression of CYP genes in families CYP1 through CYP4 in human adult and fetal liver.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Base Sequence
  • Cytochrome P-450 Enzyme System / biosynthesis*
  • Cytochrome P-450 Enzyme System / genetics
  • Cytochrome P-450 Enzyme System / metabolism
  • DNA Primers
  • Gene Expression
  • Humans
  • Isoenzymes / metabolism*
  • Liver / embryology
  • Liver / enzymology*
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • RNA, Messenger / metabolism
  • Xenobiotics / metabolism*


  • DNA Primers
  • Isoenzymes
  • RNA, Messenger
  • Xenobiotics
  • Cytochrome P-450 Enzyme System