34 radioulcer patients were divided randomly into two groups, the TCM-WM group (17 cases) and the WM group (17 cases). The TCM-WM group was treated mainly with oral administration and external treatment of TCM plus wet-compressing with antibiotics, gradual elimination of necrotic tissue and symptomatic treatment. The latter group was treated with Western medicine therapy only including pain-killer, antibiotics, debridement and dressing change. The results showed that the total effective rate of TCM-WM group was 94.1%, significantly higher than that (52.9%) of WM group (P < 0.01). Meanwhile the mean pain-ceasing time, wound-cleaning time and effective time of the TCM-WM group were 62.18, 80.16 and 107.55 days respectively, significantly shorter than those (97.29, 116.86 and 169.83 days) of WM group (P < 0.010-005). This study suggested that the TCM-WM therapy could reduce pain quickly, clean wound well, promote granulation growth and epithelium regeneration so as to accelerate ulcer healing.