Repetitive and compulsive behavior in frontal lobe degenerations

J Neuropsychiatry Clin Neurosci. Spring 1994;6(2):100-13. doi: 10.1176/jnp.6.2.100.

Abstract

The authors review the relationship of repetitive behaviors to frontal lobe degenerations and report the repetitive and compulsive behaviors, radiologic imaging findings, and neuropathology of 3 patients with dementia secondary to frontal lobe degeneration. These 3 patients and 78% of 46 proven pathologic cases of frontal lobe degeneration described in the literature demonstrate repetitive behaviors ranging from motor stereotypies to complex obsessive-compulsive disorder. This review suggests that combined damage to the frontal lobe, caudate nucleus, and globus pallidus may account for the repetitive behaviors seen in frontal lobe degenerations, idiopathic obsessive-compulsive disorder, and other neuropsychiatric diseases.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brain Mapping
  • Caudate Nucleus / pathology
  • Caudate Nucleus / physiopathology
  • Compulsive Behavior / diagnosis
  • Compulsive Behavior / pathology
  • Compulsive Behavior / physiopathology*
  • Dementia / diagnosis
  • Dementia / pathology
  • Dementia / physiopathology
  • Female
  • Frontal Lobe / pathology
  • Frontal Lobe / physiopathology*
  • Globus Pallidus / pathology
  • Globus Pallidus / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Nerve Degeneration / physiology*
  • Neurocognitive Disorders / diagnosis
  • Neurocognitive Disorders / pathology
  • Neurocognitive Disorders / physiopathology*
  • Obsessive-Compulsive Disorder / diagnosis
  • Obsessive-Compulsive Disorder / pathology
  • Obsessive-Compulsive Disorder / physiopathology*
  • Recurrence
  • Stereotyped Behavior / physiology
  • Tomography, Emission-Computed
  • Tomography, Emission-Computed, Single-Photon