Neutrophils may contribute to the morbidity and mortality of claudicants

Br J Surg. 1994 Jun;81(6):790-8. doi: 10.1002/bjs.1800810604.


Peripheral arterial occlusive disease is a common cause of morbidity in middle-aged men; 5 per cent of those aged over 50 years suffer from intermittent claudication. While claudication itself is not fatal, claudicants have a mortality rate approximately three times that of non-claudicating men of the same age, mainly from cardiovascular disease. This review examines the evidence for involvement of the neutrophil in this increased mortality and describes the possible pathogenesis. It also discusses how treatment of claudication may modify neutrophil behaviour, reducing subsequent mortality and morbidity rates.

Publication types

  • Review

MeSH terms

  • Aged
  • Cell Communication / physiology
  • Endothelium, Vascular / pathology
  • Free Radicals / metabolism
  • Humans
  • Intermittent Claudication / blood*
  • Intermittent Claudication / drug therapy
  • Intermittent Claudication / etiology
  • Intermittent Claudication / mortality
  • Leukocyte Count
  • Male
  • Microcirculation / pathology
  • Middle Aged
  • Morbidity
  • Neutrophils / metabolism
  • Neutrophils / physiology*


  • Free Radicals