Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
, 13 (14), 3286-95

c-Myc-induced Apoptosis in Fibroblasts Is Inhibited by Specific Cytokines

Affiliations
Comparative Study

c-Myc-induced Apoptosis in Fibroblasts Is Inhibited by Specific Cytokines

E A Harrington et al. EMBO J.

Abstract

We have investigated the mechanism by which deregulated expression of c-Myc induces death by apoptosis in serum-deprived fibroblasts. We demonstrate that Myc-induced apoptosis in low serum is inhibited by a restricted group of cytokines, principally the insulin-like growth factors and PDGF. Cytokine-mediated protection from apoptosis is not linked to the cytokines' abilities to promote growth. Protection from apoptosis is evident in the post-commitment (mitogen-independent) S/G2/M phases of the cell cycle and also in cells that are profoundly blocked in cell cycle progression by drugs. Moreover, IGF-I inhibition of apoptosis occurs in the absence of protein synthesis, and so does not require immediate early gene expression. We conclude that c-Myc-induced apoptosis does not result from a conflict of growth signals but appears to be a normal physiological aspect of c-Myc function whose execution is regulated by the availability of survival factors. We discuss the possible implications of these findings for models of mammalian cell growth in vivo.

Similar articles

See all similar articles

Cited by 140 articles

See all "Cited by" articles

References

    1. Immunol Today. 1993 Mar;14(3):126-30 - PubMed
    1. Mol Cell Biol. 1993 Apr;13(4):2432-40 - PubMed
    1. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3516-20 - PubMed
    1. J Immunol. 1993 Aug 15;151(4):1979-88 - PubMed
    1. Cell. 1993 Aug 27;74(4):597-608 - PubMed

Publication types

MeSH terms

LinkOut - more resources

Feedback