Neurosonographic findings in full-term infants born to maternal cocaine abusers: visualization of subependymal and periventricular cysts

J Clin Ultrasound. 1994 Jun;22(5):327-33. doi: 10.1002/jcu.1870220507.


Neuroanatomical abnormalities have been linked to maternal cocaine abuse since Chasnoff et al's report of cerebral infarction in a single full-term offspring of a cocaine-abusing mother. Neurosonography was performed on 18 full-term offspring of cocaine-abusing mothers and 19 age-matched controls to look for possible abnormalities. There were no cases of infarction or intraparenchymal or intraventricular hemorrhage. There were, however, 6 patients with abnormalities among the cocaine-abusing group: 5 patients with unilateral or bilateral germinal matrix cysts and 3 patients with subtle cystic or predominantly cystic areas in watershed zones consistent with periventricular leukomalacia.

MeSH terms

  • Adult
  • Brain / abnormalities
  • Brain Diseases / diagnostic imaging
  • Caudate Nucleus / diagnostic imaging
  • Cerebral Hemorrhage / diagnostic imaging
  • Cerebral Infarction / diagnostic imaging
  • Cerebral Ventricles / diagnostic imaging*
  • Cocaine*
  • Crack Cocaine*
  • Cysts / diagnostic imaging*
  • Echoencephalography*
  • Ependyma / diagnostic imaging*
  • Female
  • Humans
  • Infant, Newborn
  • Leukomalacia, Periventricular / diagnostic imaging
  • Male
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Substance-Related Disorders*
  • Thalamus / diagnostic imaging


  • Crack Cocaine
  • Cocaine