Paraneoplastic vasculitic neuropathy: immunohistochemical studies on a biopsied nerve and post-mortem examination

J Intern Med. 1994 Aug;236(2):225-30. doi: 10.1111/j.1365-2796.1994.tb01287.x.


We studied a patient with paraneoplastic vasculitic neuropathy (PVN) associated with a carcinoma of the common bile duct. Immunohistochemical analysis of the biopsied sural nerve showed that the cellular infiltrates in the vascular lesions were composed primarily of CD8-positive T lymphocytes and macrophages. Pathogenic significance of the T-cell-mediated immunological reaction was suggested. Post-mortem examination revealed the absence of systemic vasculitis, which may be a characteristic feature of PVN. The patient responded to immunosuppressive treatment. We discuss the efficacy and the risk of immunosuppressive therapy for PVN.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma / complications
  • Adenocarcinoma / pathology*
  • Common Bile Duct Neoplasms / complications
  • Common Bile Duct Neoplasms / pathology*
  • Humans
  • Male
  • Middle Aged
  • Paraneoplastic Syndromes / etiology
  • Paraneoplastic Syndromes / pathology*
  • Peripheral Nervous System Diseases / etiology
  • Peripheral Nervous System Diseases / pathology*
  • Sural Nerve / pathology
  • Vasculitis / etiology
  • Vasculitis / pathology*