Raf meets Ras: completing the framework of a signal transduction pathway

Trends Biochem Sci. 1994 Jul;19(7):279-83. doi: 10.1016/0968-0004(94)90005-1.


The Ras oncoprotein, a GTP-activated molecular switch, interacts directly with the Raf oncoprotein to recruit the MAP kinases and their subordinates. In this way, a mitogenic signal initiated by tyrosine kinases is converted by Ras into a wave of regulatory phosphorylation on serine and threonine residues that, depending on its intensity and duration, and the variety of substrates available, results in cell differentiation or cell division.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Enzyme Activation
  • Humans
  • Molecular Sequence Data
  • Oncogene Protein p21(ras) / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism*
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-raf
  • Signal Transduction*


  • Proto-Oncogene Proteins
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-raf
  • Oncogene Protein p21(ras)