Clinical and experimental studies in myocarditis

Curr Opin Cardiol. 1994 May;9(3):349-56. doi: 10.1097/00001573-199405000-00014.

Abstract

We review recent manuscripts concerning the pathogenesis as well as the treatment of myocarditis. The development of myocarditis is related to inflammatory cell infiltration, progressive and additive focal cellular necrosis, and associated reactive myocardial fibrosis. These processes may be initiated and perpetuated by autoimmune factors, including cytokines, and by alterations in the myocardial microcirculation. This has implications for the development of future therapeutic strategies for patients with myocarditis, strategies that will enable physicians to optimize medical treatment and, hopefully, to improve the prognosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoantibodies / analysis
  • Biopsy
  • Cardiomyopathy, Dilated / etiology
  • Cardiomyopathy, Dilated / pathology
  • Cardiomyopathy, Dilated / therapy
  • Cytokines / physiology
  • Endocardium / pathology
  • HIV Infections / complications
  • HIV Infections / pathology
  • HIV Infections / therapy
  • Humans
  • Immunization, Passive
  • Myocarditis / etiology*
  • Myocarditis / pathology
  • Myocarditis / therapy
  • Myocardium / pathology
  • Reactive Oxygen Species / metabolism

Substances

  • Autoantibodies
  • Cytokines
  • Reactive Oxygen Species