Clinical and histological features of 'mechanic's hands' in a patient with antibodies to Jo-1--a case report

Clin Exp Dermatol. 1994 Mar;19(2):146-8. doi: 10.1111/j.1365-2230.1994.tb01144.x.


The clinical and histological features of 'mechanic's hands' are described in a patient with polymyositis characterized serologically by antibodies to histidyl tRNA synthetase (Jo-1). Although described in the past in association with polymyositis, these distinctive cutaneous lesions have only recently been associated with the 'anti-synthetase syndrome'. It is becoming apparent that recognition of subsets within the spectrum of polymyositis/dermatomyositis characterized by certain clinical and serological features not only have prognostic significance, but also may provide insights into mechanisms of disease.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies / analysis*
  • Female
  • Hand Dermatoses / immunology
  • Hand Dermatoses / pathology*
  • Histidine-tRNA Ligase / immunology*
  • Humans
  • Keratosis / immunology
  • Keratosis / pathology
  • Polymyositis / immunology
  • Polymyositis / pathology*


  • Antibodies
  • Histidine-tRNA Ligase