Decreased cerebral 5-HT1A receptors during ageing: reversal by Ginkgo biloba extract (EGb 761)

J Pharm Pharmacol. 1994 Apr;46(4):316-8. doi: 10.1111/j.2042-7158.1994.tb03802.x.


Investigation of [3H]8-hydroxy-2(di-n-propylamino)tetralin binding to 5-HT1A receptors in cerebral cortex membranes of Wistar rats showed that the maximal number of binding sites (Bmax) was reduced significantly (22%) in aged (24-month-old) as compared with young (4-month-old) animals. Chronic treatment with Ginkgo biloba extract did not alter binding in young rats but increased binding density significantly (33%) in aged rats. These results confirm previously described age-related 5-hydroxytryptaminergic alterations. Together with data in the literature, they also suggest a restorative effect in aged rats, associated with decreased receptor density resulting from the protective action of Ginkgo biloba extract treatment on neuronal membrane.

Publication types

  • Comparative Study

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin / metabolism*
  • Aging / metabolism*
  • Animals
  • Binding Sites / drug effects
  • Binding, Competitive
  • Cell Membrane / drug effects
  • Cell Membrane / metabolism
  • Cerebral Cortex / drug effects*
  • Cerebral Cortex / metabolism
  • Ginkgo biloba
  • Male
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Wistar
  • Receptors, Serotonin / drug effects*
  • Receptors, Serotonin / metabolism


  • Plant Extracts
  • Receptors, Serotonin
  • Ginkgo biloba extract
  • 8-Hydroxy-2-(di-n-propylamino)tetralin