Effect of lignocaine on eicosanoid synthesis by pieces of human gastric mucosa

J Pharm Pharmacol. 1994 Apr;46(4):319-20. doi: 10.1111/j.2042-7158.1994.tb03803.x.


Lignocaine can affect prostaglandin synthesis in various tissues, and it has anti-inflammatory activity. No studies have been made previously on human isolated gut tissues. When concentrations of 5, 50 and 250 micrograms mL-1 lignocaine were incubated with human gastric mucosa/submucosa at 37 degrees C for 30 min, only the highest concentration reduced the levels of prostaglandin E, thromboxane B2 and 6-keto-PGF1 alpha in the incubates, and leukotriene C4/D4 was unaffected. Therapeutically relevant amounts of lignocaine given parenterally would therefore seem unlikely to alter gastric mucosal prostanoids, but high doses can be given orally because of extensive first-pass metabolism in the liver.

MeSH terms

  • 6-Ketoprostaglandin F1 alpha / biosynthesis*
  • Dose-Response Relationship, Drug
  • Gastric Mucosa / drug effects*
  • Gastric Mucosa / metabolism
  • Humans
  • Lidocaine / pharmacology*
  • Prostaglandins E / biosynthesis*
  • Thromboxane B2 / biosynthesis*


  • Prostaglandins E
  • Thromboxane B2
  • 6-Ketoprostaglandin F1 alpha
  • Lidocaine