Dynamic magnetic resonance imaging for the evaluation of synovitis in patients with rheumatoid arthritis

Arthritis Rheum. 1994 Aug;37(8):1151-7. doi: 10.1002/art.1780370807.


Objective: To investigate whether the findings of magnetic resonance imaging (MRI) reflect rheumatoid synovitis.

Methods: Dynamic imaging enhanced with gadolinium-diethylenetriamine pentaacetic acid was performed on 10 affected knees of 9 patients with rheumatoid arthritis. Changes in signal intensity were correlated with pathologic findings in synovial biopsy specimens obtained during total knee arthroplasty.

Results: Enhancement was greater in regions with a higher degree of fibrin exudation, cellular infiltration, villous hypertrophy, vascular proliferation, and granulation formation.

Conclusion: Dynamic MRI can be used for assessing local disease activity in rheumatoid synovium.

MeSH terms

  • Aged
  • Arthritis, Rheumatoid / complications*
  • Arthritis, Rheumatoid / pathology
  • Female
  • Gadolinium
  • Gadolinium DTPA
  • Humans
  • Injections
  • Knee Joint
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Organometallic Compounds / administration & dosage
  • Pentetic Acid / administration & dosage
  • Pentetic Acid / analogs & derivatives
  • Synovial Membrane / pathology
  • Synovitis / complications
  • Synovitis / diagnosis*


  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA