Viral interactions with the host-cell cytoskeleton: the role of retroviral proteases

Trends Microbiol. 1994 May;2(5):178-82. doi: 10.1016/0966-842x(94)90669-6.


A surprisingly large number of animal viruses interact with cytoskeletal elements inside infected cells at different stages of replication. For example, a viral protease is activated during assembly of murine leukemia viruses at the cell surface, which causes both the morphological conversion of 'immature' to 'mature' particles and a drastic reduction of the actin stress fiber network.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytoskeleton / metabolism*
  • Endopeptidases / physiology*
  • HIV / enzymology
  • HIV Protease / physiology*
  • Humans
  • Leukemia Virus, Murine / enzymology*
  • Leukemia Virus, Murine / physiology
  • Models, Biological
  • Virus Replication / physiology


  • Endopeptidases
  • HIV Protease