Propofol inhibits phagocytosis and killing of Staphylococcus aureus and Escherichia coli by polymorphonuclear leukocytes in vitro

Can J Anaesth. 1994 May;41(5 Pt 1):446-9. doi: 10.1007/BF03009871.

Abstract

Polymorphonuclear leukocytes (PMNL) are important components of the immunological defence system which protects the human organism from invading bacteria. Using a fluorescence microscopic method, we examined the influence of propofol and its solvent intralipid on phagocytosis and killing of Staphylococcus aureus and Escherichia coli by PMNL in vitro. Propofol inhibited (P < or = 0.001) phagocytosis of Staphylococcus aureus as well as Escherichia coli. Killing of Staphylococcus aureus (P < or = 0.001) and of Escherichia coli (P < or = 0.01) was suppressed. Intralipid, by itself, impaired phagocytosis of Escherichia coli (P < or = 0.05). Apart from that, intralipid produced no relevant effects. Additional clinical studies regarding the influence of propofol on PMNL function are recommended.

MeSH terms

  • Adult
  • Bacteriolysis / drug effects
  • Cells, Cultured
  • Escherichia coli / physiology*
  • Fat Emulsions, Intravenous / pharmacology
  • Humans
  • Male
  • Microscopy, Fluorescence
  • Neutrophils / drug effects*
  • Neutrophils / immunology
  • Neutrophils / physiology
  • Phagocytosis / drug effects*
  • Phagocytosis / physiology
  • Propofol / pharmacology*
  • Staphylococcus aureus / physiology*

Substances

  • Fat Emulsions, Intravenous
  • Propofol