Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. May-Jun 1994;49(3):181-92.

[Potential Anticancer and Antiparasitic Indole Alkaloids]

[Article in French]
  • PMID: 8057233

[Potential Anticancer and Antiparasitic Indole Alkaloids]

[Article in French]
J Quetin-Leclercq. J Pharm Belg. .


Many drugs are derived from active molecules isolated from plants or micro-organisms. Nevertheless, a lot of species have not yet been studied; they constitute an important source of new structures that could possess interesting pharmacological activities and/or original modes of action, for example in the field of anticancer or antiparasitic drugs (taxol, artemisinin, swainsonine, camptothecin,...). Among all the bioactive natural products, we studied more particularly indole alkaloids extracted from different tropical Strychnos species. Several new alkaloids have been isolated from cytotoxic crude extracts. Some of them possess interesting cytotoxic, antitumor or antiparasitic properties. We also realised molecular modelling studies in order to explain the activity of usambarensine.

Similar articles

See all similar articles

Cited by 10 articles

See all "Cited by" articles

MeSH terms