Abstract
We have observed that respiratory virus infection of mice provokes an extremely persistent humoral immune reaction, due to a long-sustained population of antibody-secreting cells in the bone marrow. Theories of humoral immunity that strongly distinguish primary and secondary reactions thus may not adequately describe the immune response to respiratory viruses.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Viral / biosynthesis*
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Antibody Formation
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Antibody-Producing Cells
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Bone Marrow / immunology
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Bone Marrow Cells
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Influenza A virus / immunology*
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Mice
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Mice, Inbred C57BL
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Parainfluenza Virus 1, Human / immunology*
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Paramyxoviridae Infections / immunology*
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Time Factors