3D MPRAGE evaluation of lesions in the posterior cranial fossa

Magn Reson Imaging. 1994;12(4):553-8. doi: 10.1016/0730-725x(94)92449-x.


Standard spin-echo images of the posterior cranial fossa are usually impaired by pulsation artifacts. We evaluated a heavily T1 weighted MPRAGE sequence (TR/TE/alpha/TI = 10/4/10-15 degrees/200-350) for detection of intracerebral lesions in the posterior fossa in 11 patients. Overall quality of the MPRAGE images was superior due to the lack of pulsation artifacts, high S/N and excellent gray-white matter contrast. Lesion detection was better in one patient, equal in six and inferior in four patients compared to SE technique. A cerebellar metastasis (8 mm) in one patient was completely blurred from pulsation artifacts on the SE images. Whereas multiple small lesions (< or = 4 mm) with discrete contrast enhancement were missed on the MPRAGE images in three patients. We conclude, that the MPRAGE sequence yields high quality images with isotropic spatial resolution in a reasonable time. But MPRAGE with these parameters can not replace standard SE images in screening the posterior fossa, because of a decreased sensitivity in the detection of small contrast-enhancing lesions.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Cranial Fossa, Posterior / pathology*
  • Female
  • Humans
  • Infratentorial Neoplasms / diagnosis*
  • Infratentorial Neoplasms / secondary
  • Magnetic Resonance Imaging* / methods
  • Male
  • Middle Aged
  • Prospective Studies