Imaging Endogenous Dopamine Competition With [11C]raclopride in the Human Brain

Synapse. 1994 Apr;16(4):255-62. doi: 10.1002/syn.890160402.

Abstract

This study images dopamine release in response to a neurochemically specific challenge with the psychostimulant drug methylphenidate. Changes in synaptic dopamine induced by methylphenidate were evaluated with positron emission tomography and [11C]raclopride, a D2 receptor radioligand that is sensitive to endogenous dopamine. Methylphenidate significantly decreased striatal [11C]raclopride binding. The decrease was variable and was negatively correlated with age. Mood and anxiety at baseline, were also correlated with methylphenidate-induced DA changes. This strategy provides a tool to investigate the responsiveness of the dopamine system in the normal and diseased human brain and to investigate the neurochemical correlates of behavior.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Affect / physiology
  • Anxiety / metabolism
  • Basal Ganglia / diagnostic imaging
  • Basal Ganglia / metabolism
  • Binding, Competitive / drug effects
  • Brain / diagnostic imaging
  • Brain / drug effects
  • Brain / metabolism*
  • Brain Chemistry / drug effects
  • Brain Chemistry / physiology*
  • Cerebrovascular Circulation / physiology
  • Dopamine / metabolism*
  • Dopamine D2 Receptor Antagonists*
  • Humans
  • Male
  • Methylphenidate / pharmacokinetics
  • Methylphenidate / pharmacology
  • Middle Aged
  • Neostriatum / diagnostic imaging
  • Neostriatum / drug effects
  • Neostriatum / metabolism
  • Raclopride
  • Salicylamides / pharmacokinetics*
  • Synapses / metabolism
  • Tomography, Emission-Computed

Substances

  • Dopamine D2 Receptor Antagonists
  • Salicylamides
  • Methylphenidate
  • Raclopride
  • Dopamine