Mortality in HIV-1-seropositive women, their spouses and their newly born children during 36 months of follow-up in Kinshasa, Zaïre

AIDS. 1994 May;8(5):667-72. doi: 10.1097/00002030-199405000-00014.


Objective: To calculate 3-year mortality rates in HIV-1-seropositive and HIV-1-seronegative mothers, their newborn children and the fathers of these children.

Design: Longitudinal cohort study of HIV-1-seropositive, age and parity-matched HIV-1-seronegative pregnant women, their newborn babies and the fathers of these children.

Setting: Obstetric ward and follow-up clinic at a large municipal hospital in Kinshasa, Zaïre.

Participants: A total of 335 newborn children and their 327 HIV-1-seropositive mothers and 341 newborn children and their 337 HIV-1-seronegative mothers and the fathers of these children.

Main outcome measures: Rates of vertical HIV-1 transmission and maternal, paternal and early childhood mortality.

Results: The lower and upper bounds of vertical transmission were 27 and 50%, respectively. The 3-year mortality rate was 44% in children with vertically acquired HIV-1 infection, 25% in children with HIV-1-seropositive mothers and indeterminant HIV-1 infection status, and 6% in uninfected children with HIV-1-seronegative mothers. HIV-1-seropositive women who transmitted HIV-1 infection to their most recently born child had lost a greater number of previously born children (mean, 1.5 versus 0.5; P < 0.05), were more likely to have had AIDS at delivery (25 versus 12%; P < 0.01) and were more likely to die during follow-up (22 versus 9%; P < 0.01) than HIV-1-seropositive women who did not transmit HIV-1 infection to their newborn child. Twenty-five out of 239 (10.4%) fathers of children with HIV-1-seropositive mothers, not lost to follow-up, died compared with three out of 310 (1%) fathers of children with HIV-1-seronegative mothers (P < 0.01).

Conclusions: Families in Kinshasa, Zaïre, in which the mother was HIV-1-seropositive experienced a five to 10-fold higher maternal, paternal and early childhood mortality rate than families in which the mother was HIV-1-seronegative.

MeSH terms

  • Acquired Immunodeficiency Syndrome / mortality
  • Adult
  • Cohort Studies
  • Democratic Republic of the Congo / epidemiology
  • Diseases in Twins / epidemiology
  • Family Health
  • Fathers
  • Female
  • HIV Infections / congenital
  • HIV Infections / epidemiology
  • HIV Infections / transmission
  • HIV Seropositivity / mortality*
  • HIV-1*
  • Humans
  • Infant, Newborn
  • Life Tables
  • Male
  • Parity
  • Pregnancy
  • Pregnancy Complications, Infectious / epidemiology*
  • Prospective Studies
  • Sexual Partners
  • Survival Analysis