Dark adaptation in patients with Best vitelliform macular dystrophy

Br J Ophthalmol. 1994 Jun;78(6):430-2. doi: 10.1136/bjo.78.6.430.


Psychophysical dark adaptation studies were performed in six patients with Best vitelliform macular dystrophy (BVMD) using a Goldmann-Weekers dark adaptometer. Prebleach thresholds were determined before obtaining a postbleach full recovery curve. Unlike patients with Stargardt macular dystrophy, all patients with BVMD showed a normal time to reach their baseline dark adapted thresholds after bleaching of their rod visual pigment when tested in clinically normal appearing retina. Although a lipofuscin material accumulates within retinal pigment epithelial cells in patients with either Best or Stargardt dystrophy, functional findings pertaining to recovery of rod dark adaptation thresholds as well as electro-oculogram light peak to dark trough ratios are different in these two disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Dark Adaptation / physiology*
  • Female
  • Humans
  • Kinetics
  • Macular Degeneration / physiopathology*
  • Male
  • Psychophysics
  • Retinal Cone Photoreceptor Cells / physiopathology
  • Retinal Rod Photoreceptor Cells / physiopathology
  • Sensory Thresholds / physiology