Tumor microvasculature following fractionated x irradiation

Radiology. 1975 Jul;116(1):165-9. doi: 10.1148/116.1.165.

Abstract

The microvasculature of C3H/Bi mouse mammary carcinomas 8 mm in average diameter was evaluated using morphometric methods following six consecutive daily exposures of 500 R of x radiation. Tumor volume did not change significantly during the intervals between treatments. Tumors began to grow again 72 hours after the sixth 550-R fraction, with mean vessel length and surface area reaching maximum values and vessel diameters and volumes becoming minimal at this time. These changes were attributed to improved colloidal-carbon filling of previously existing nonfunctional vessles. When anatomically derived estimates of vascular dimensions were related to a metabolically useful blood supply, improved capability for exchange of essential nutrients occurred 72 hours after the sixth 500-R fraction.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Carbon
  • Colloids
  • Contrast Media
  • Mammary Neoplasms, Experimental / pathology
  • Mammary Neoplasms, Experimental / radiotherapy*
  • Mice
  • Mice, Inbred Strains
  • Microcirculation / pathology
  • Microcirculation / radiation effects*
  • Neoplasm Transplantation
  • Radiation Effects*
  • Radiotherapy Dosage
  • Radiotherapy, High-Energy
  • Thigh / surgery

Substances

  • Colloids
  • Contrast Media
  • Carbon