The myb oncogene family of transcription factors: potent regulators of hematopoietic cell proliferation and differentiation

Semin Cancer Biol. 1994 Apr;5(2):113-24.


The myb family of genes includes the virally encoded v-myb oncogene, the c-myb protooncogene from which it is derived, and two structurally related genes, B-myb and A-myb. C-myb is most highly expressed in hematopoietic cells and its oncogenic activation leads to transformation, primarily of myeloid cells. Several lines of evidence suggest that c-myb functions in regulating both the proliferation and differentiation of hematopoietic cells of different lineages, including early progenitors. The mechanisms of action and the regulation of expression of c-myb and v-myb will be described. The possible role of the B-myb and A-myb gene products will also be discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Base Sequence
  • Cell Differentiation / physiology
  • Cell Division / physiology
  • Cell Transformation, Neoplastic / genetics
  • Hematopoietic Stem Cells / cytology*
  • Molecular Sequence Data
  • Multigene Family*
  • Oncogenes*
  • Transcription Factors / genetics*


  • Transcription Factors