The association between age and bone mineral density in men and women aged 55 years and over: the Rotterdam Study

Bone Miner. 1994 Apr;25(1):1-13. doi: 10.1016/s0169-6009(08)80203-6.


In this cross-sectional study, bone mineral density (BMD) measurements were performed in 1762 ambulatory subjects (678 men and 1084 women) aged 55 years and over from the Rotterdam Study, a population based study of diseases in the elderly. BMD measurements of the proximal femur and lumbar spine were performed using dual energy X-ray absorptiometry. No age-related decline in BMD could be observed in the lumbar spine. Yearly percentage BMD reduction in women and men was -0.6% and -0.3% in the femoral neck, -0.8% and -0.5% in the Ward's triangle, and -0.4% and -0.3% in the trochanter, respectively. Late menopause was associated with high BMD in Ward's triangle and lumbar spine. We conclude that: (1) accurate assessment of age-related bone reduction in the spine is impossible from cross-sectional studies since BMD measurements in the elderly may be influenced by spinal osteoarthritis; and (2) the rate of age-related bone reduction in the femoral neck appears to be approximately two times higher in women than in men.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon
  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Bone Density / physiology*
  • Cross-Sectional Studies
  • Female
  • Femur / physiology
  • Humans
  • Lumbar Vertebrae / physiology
  • Male
  • Menopause
  • Middle Aged
  • Netherlands
  • Sex Characteristics