Effect of GSH depletion mediated by l-BSO on the insecticidal activity of DDT and fenitrothion in Triatoma infestans (Hemiptera)

Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 1994 May;108(1):39-42. doi: 10.1016/1367-8280(94)90086-8.

Abstract

l-BSO injected at a sublethal dose in nymph V of Triatoma infestans produces a transient GSH depletion in the abdomen. A depletion of the total content of GSH was observed in nymph II fed with a sublethal concentration of l-BSO. Either ingestion or injection pretreatments of T. infestans nymph V with sublethal concentrations of l-BSO produced a slight synergism on the toxicity of fenitrothion. Feeding administration of a sublethal concentration of l-BSO to nymphs II of T. infestans resulted in a weak potentiation of the acute toxicity of DDT.

MeSH terms

  • Animals
  • Buthionine Sulfoximine
  • DDT / toxicity*
  • Fenitrothion / toxicity*
  • Glutathione / metabolism*
  • Methionine Sulfoximine / analogs & derivatives*
  • Methionine Sulfoximine / pharmacology
  • Pesticide Synergists / pharmacology*
  • Triatoma / drug effects*
  • Triatoma / metabolism

Substances

  • Pesticide Synergists
  • Methionine Sulfoximine
  • Buthionine Sulfoximine
  • DDT
  • Glutathione
  • Fenitrothion