Age-specific antibody prevalence to hepatitis A in England: implications for disease control

Epidemiol Infect. 1994 Aug;113(1):113-20. doi: 10.1017/s0950268800051529.


Sera from an age-stratified sample of 7196 individuals, submitted for diagnostic purposes to four public health laboratories in England in 1986/7, were tested for hepatitis A antibody. The serological profiles, which showed marked regional differences, were consistent with declining incidence in the past. The decline in the incidence of hepatitis A has resulted in an increase in susceptibility in adults. This has three main consequences: an increase in the average age of infection may be leading to an increase in morbidity; normal immunoglobulin may become less protective against hepatitis A; the risk of transmission through blood products contaminated by viraemic blood donors may rise. Current average annual incidence in 5-14-year olds was estimated to vary between regions from 0.5-1.9%. This supports the view that, in the absence of a vaccination programme, hepatitis A will remain endemic unless there are further improvements in living conditions and standards of hygiene. A vaccine giving long-lasting protection could eliminate hepatitis A transmission with modest coverage at a young age. Targeting childhood vaccination on economically deprived areas or using vaccine to control outbreaks might be more effective policies.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • England / epidemiology
  • Female
  • Hepatitis A / epidemiology*
  • Hepatitis A / immunology
  • Hepatitis A / prevention & control
  • Hepatitis A Antibodies
  • Hepatitis A Vaccines
  • Hepatitis Antibodies / blood*
  • Hepatovirus / immunology*
  • Humans
  • Incidence
  • Infant
  • Male
  • Middle Aged
  • Morbidity
  • Prevalence
  • Viral Hepatitis Vaccines


  • Hepatitis A Antibodies
  • Hepatitis A Vaccines
  • Hepatitis Antibodies
  • Viral Hepatitis Vaccines